2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137544
    16-Phenyl tetranor Prostaglandin F2α
    16-phenyl tetranor Prostaglandin F2α (16-phenyl tetranor PGF2α) is a metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2α.
    16-Phenyl tetranor Prostaglandin F2α
  • HY-113083R
    Acetaminophen glucuronide (Standard)
    Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
    Acetaminophen glucuronide (Standard)
  • HY-138166
    Rosuvastatin lactone
    Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor).
    Rosuvastatin lactone
  • HY-W158239
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid is a metabolite of GW 501516 (HY-10838).
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid
  • HY-130465
    7α-Thiospironolactone
    7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus.
    7α-Thiospironolactone
  • HY-135595
    6-Raloxifene-β-D-glucopyranoside
    6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A.
    6-Raloxifene-β-D-glucopyranoside
  • HY-B1415S
    Clofibric acid-d4
    Clofibric acid-d4 is the deuterium labeled Clofibric acid. Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide[1][2][3].
    Clofibric acid-d<sub>4</sub>
  • HY-136445R
    Terbuthylazine-desethyl (Standard)
    Terbuthylazine-desethyl (Standard) is the analytical standard of Terbuthylazine-desethyl. This product is intended for research and analytical applications. Terbuthylazine-desethyl (Desethylterbuthylazine) is a chloro dealkylated metabolite of Terbuthylazine (a triazine herbicide).
    Terbuthylazine-desethyl (Standard)
  • HY-128696R
    Amlodipine aspartic acid impurity (Standard)
    1-Bromonaphthalene (Standard) is the analytical standard of 1-Bromonaphthalene. This product is intended for research and analytical applications. 1-Bromonaphthalene is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Amlodipine aspartic acid impurity (Standard)
  • HY-136347
    3α-Hydroxy pravastatin sodium
    		99.35%
    3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor.
    3α-Hydroxy pravastatin sodium
  • HY-116016R
    Etilevodopa (Standard)
    Chlorbenside (Standard) is the analytical standard of Chlorbenside. This product is intended for research and analytical applications. Chlorbenside is an organochlorine pesticide. Chlorbenside targets organism such as mites and ticks and possesses efficient ovicidal and larvicidal activities.
    Etilevodopa (Standard)
  • HY-119359
    5,6-Epoxy-13-cis retinoic acid
    5,6-Epoxy-13-cis retinoic acid (Isotretinoin EP impurity G) is a metabolite of 13-cis retinoic acid.
    5,6-Epoxy-13-cis retinoic acid
  • HY-143907S
    Atorvastatin EP impurity H-d5
    Atorvastatin EP impurity H-d5 is the deuterium labeled Atorvastatin EP impurity H[1].
    Atorvastatin EP impurity H-d<sub>5</sub>
  • HY-147327
    N-Formylsarcolysine
    N-Formylsarcolysine has antitumor activity, and inhibits leukemia by increasing the Hb and erythrocyte levels and decreasing the number of leukocytes. N-Formylsarcolysine also involves in glioblastoma and other diseases research.
    N-Formylsarcolysine
  • HY-W011235R
    Norfluoxetine (hydrochloride) (Standard)
    Arecoline (hydrobromide) (Standard) is the analytical standard of Arecoline (hydrobromide). This product is intended for research and analytical applications. Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress.
    Norfluoxetine (hydrochloride) (Standard)
  • HY-W050000R
    OR-1855 (Standard)
    Tanshinone IIA sulfonate (sodium) (Standard) is the analytical standard of Tanshinone IIA sulfonate (sodium). This product is intended for research and analytical applications. Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.
    OR-1855 (Standard)
  • HY-137773
    N-Methyl pemetrexed
    N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer.
    N-Methyl pemetrexed
  • HY-118548
    Tetranor-PGAM
    Tetranor-PGAM is a tetranor-prostaglandin A metabolite. Tetranor-PGAM is a dehydration product of tetranor-PGEM (HY-114988). Tetranor-PGAM can be measured as a surrogate for tetranor-PGEM levels in urine.
    Tetranor-PGAM
  • HY-148051
    Ilaprazole sulfone
    Ilaprazole sulfone is the major metabolite of Ilaprazole (HY-101664), is predominantly catalysed by CYP3A4/5. Ilaprazole (IY-81149) is an orally active proton pump inhibitor.
    Ilaprazole sulfone
  • HY-W008216S
    HMMNI-d3
    HMMNI-d3 is deuterium labeled HMMNI. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class agent that combats protozoan infections[1].
    HMMNI-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity